Please see this new paper in Nature Microbiology:
https://www.nature.com/articles/s41564-019-0380-2
This systematic review included over 400 published studies. The main conclusion is that TB biomarker discovery studies are often poorly designed and findings are rarely confirmed in independent studies. Few markers progress to a further developmental stage. More validation studies that consider the intended diagnostic use cases and apply rigorous design are needed.
PDF attached.
Best
Madhu
MacLean Broger Nature Micro 2019.pdf (1.6 MB)