Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis: A Diagnostic Study

Discussion
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Please see the study below which assessed the sensitivity of blood cultures obtained after initiation of antimicrobial therapy in adults with severe manifestations of sepsis.
The study observed that initiation of empirical antimicrobial therapy significantly reduces the sensitivity of blood cultures drawn shortly after treatment initiation.

https://annals.org/aim/article-abstract/2751453/blood-culture-results-before-after-antimicrobial-administration-patients-severe-manifestations